A type of arthritis in the spine, causing inflammation and gradual fusing of the vertebrae. Early signs and symptoms include pain and stiffness in the lower back and hips.

The symptoms are more evident in the morning or following long duration of inactivity

Other symptoms noted include:

Neck pain

Back pain

Fatigue

Fever

Loss of appetite

This is an inflammatory arthropathy, primarily involving the sacroiliac joints and the spine with a marked tendency to ankylosing (fusion). The precise aetiology is not known. A large number of patients show the presence of HLA-B27 antigen. Patients are commonly young men in the third decade. The initial symptom is a low backache with morning stiffness due to involvement of sacroiliac joint. Later on, the spine in involved from below upwards (sparing the cervical spine). At a still later stage the proximal joints of the limbs, particularly the hip joints are affected. The disease is progressive and leads to crippling deformities. Iritis and prostatourethritis are commonly associated. The diagnosis can be confirmed by radiography which shows obliteration of the sacroiliac joints in the early stage and the characteristic bamboo spine at a later stage.

The exact cause for ankylosing spondylitis is not known. Gene mutation could be factor.

Other factors that could contribute to ankylosing spondylitis include:

Gender: Men are at increased risk than women

Age: The disease tends to develop during late adolescence or early adulthood

Family history

Fusion of the vertebrae in the affected part is one of the main complications. This leads to:

Stiffness and inflexibility in the affected part – hip joints especially may require hip replacement

Hunched forward posture

Difficulty in breathing, when ribs are affected

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